Mostly Biomathematics Lunchtime Seminar

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Individualized multiple myeloma adaptive response modeling: mathematics for better treatment decisions

Speaker: Guanyu Wang, Courant Institute of Mathematical Sciences, New York University

Location: Warren Weaver Hall 1314

Date: Tuesday, March 20, 2018, 12:30 p.m.

Synopsis:

Current treatment paradigms for the majority of cancers bin patients into ordinal response categories, potentially leading to clinical decisions that may make sense on the population level but are potentially suboptimal for guiding individual patient care. We implemented a nonlinear mixed-effects model of the kinetics of disease burden in multiple myeloma. Then we built a prototype tool for adaptively estimating an individual patient’s future response trajectory and progression free survival probability from that patient’s initial response data, and predicting that patient’s response under alternative treatment scenarios. We believe that this methodology has the potential to impact the way patient-level decisions are made and ultimately improve outcomes for patients with multiple myeloma.