Biomathematics / Computational Biology Colloquium

Analysis of Global Dynamics of Regulatory Networks: A Novel Mathematical Approach

Speaker: Konstantin Mischaikow, Department of Mathematics, Rutgers, The State University of New Jersey

Location: Warren Weaver Hall 1314

Date: Tuesday, January 30, 2018, 12:30 p.m.


Using the Rb/E2F pathway as a model, I will present a novel approach to nonlinear dynamics based on combinatorial and topological techniques.  This approach has several important consequences including the ability to give a well defined finite representation of dynamics, to rigorously describe dynamics over large sets of parameter values, and the fact that it computationally accessible.  As a particular, application I will describe how the associated software DSGRN can be used to search for simple robust models of the switching behavior that is at the heart of the Rb/E2F pathway.