Mostly Biomathematics Lunchtime Seminar

---

Rates and states

Speaker: Glen M. Hocky, New York University

Location: Warren Weaver Hall 1314

Date: Tuesday, October 22, 2024, 12:45 p.m.

Synopsis:

A major thrust of my research group is advancing computational techniques to determine how cells use proteins to sense and respond to mechanical forces. Many mechanosensing proteins have been discovered that are believed to change their behavior in a predictable and repeatable way when they are under mechanical tension. Yet, in most of these cases, we don't know the molecular details of how this force shifts the conformations adopted by the protein, or how this then leads to a concomitant change in function. In this talk, I will overview our efforts to develop computational techniques to attack this problem, and in particular I will describe recent advances we have made that allow us to cluster and sample between states of biomolecules, and to predict rates of those transitions.