Mostly Biomathematics Lunchtime Seminar

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Direct simulation of projection-based thalamocortical connectome reproduces spatiotemporal patterns of sensory-evoked activity

Speaker: Guanhua Sun, PhD Candidate, Department of Mathematics, University of Michigan

Location: Warren Weaver Hall 1314

Date: Tuesday, November 26, 2024, 12:45 p.m.

Synopsis:

Large-scale spatiotemporal patterns, such as traveling waves, are prevalent in different brain regions across species. Those spatiotemporal patterns are linked to critical functions such as memory, sleep, and vision, but our understanding of them remains limited. Due to the difficulty of measurements, computational models have been useful in such exploration. In my talk, I will first present an algorithm to reconstruct a thalamocortical connectome(N~430,000) of the mouse brain with currently available data. I will then describe a computation model consisting of single-compartment Hodgkin-Huxley neurons based on the constructed connectome. Lastly, I will show some direct simulations of the computational model that manage to reproduce the experimental results(1) qualitatively. This is an ongoing project and the talk will last about 35 - 40 minutes.