Modeling and Simulation Group Meeting Old

An Inverse Problem in the Crossbridge Dynamics of Muscle

Speaker: Charlie Peskin, partner: Xuenan Li, Courant

Location: Warren Weaver Hall 1302

Date: Thursday, February 17, 2022, 12:30 p.m.


In the 1930s, A.V. Hill made careful macroscopic measurements on the
mechanics and thermodynamics of contracting muscle.  In this talk,
we use Hill's observations to determine molecular properties of the
central engine of muscle contraction, which is called the crossbridge.
Despite some loose ends, our results are in striking overall agreement
with 21st-century data.